Properties[ edit ] The classical definition of a stem cell requires that it possesses two properties: In the strictest sense, this requires stem cells to be either totipotent or pluripotent —to be able to give rise to any mature cell type, although multipotent or unipotent progenitor cells are sometimes referred to as stem cells.
And, for the health professionals who serve them. Many topics and insights I would now include are missing. The original concept of this treatise was to look at the main existing scientific theories of aging, see what they have in common, see what each has to say about steps that could be taken to halt or delay aging, and combine these steps into an overall "antiaging firewall.
This was a good concept and it has personally served me well.
However, my thinking about health and aging has continued to become more sophisticated and nuanced and the science itself has also evolved significantly during the period.
Also, my personal anti-aging lifestyle and dietary interventions have continued to evolve in a way not captured here. I will eventually rewrite this treatise from a different perspective.
Here is a brief history of what has happened and where to look for my latest thoughts: The birth of the blog Seven years ago, I thought that I could continue to update this treatise as I followed the key scientific streams related to health and aging.
Soon, I discovered that for older people, creating health and creating longevity amount to the same thing. And, to know how to do that based on new scientific discoveries, it was necessary to consider vast, disparate and detailed bodies of scientific knowledge.
Over 1 million potentially relevant scientific papers are now published every year. It would be completely impossible to encompass even summaries of the relevant knowledge in this one treatise.
So, I created the Aging Sciences Blog as a vehicle for communicating about particularly relevant topics. The blog rapidly became my main vehicle for writing up what I have learned. It served the initial objective of making sure that I understand a topic by forcing me to lay it out in writing in comprehensive form.
Soon, a second objective emerged for the blog - communicating this information to a wider audience, getting feedback and networking myself with other researchers. Research, communicating personally about research and writing for the blog became my major activities, and further updating of this treatise became increasingly secondary.
As time has progressed my appreciation and understanding of the detailed sciences involved in aging and health have multiplied severalfold. And yet, the more I learn the more obvious it is that there is much more yet to be learned.
It seems that for everything I learn, I discover there are at least two new things yet to be learned. Early-on, I started posting longer blog posts that go into considerable depth. The blog now July 3, includes over posts and thousands of comments.
On the average, 5, to 6, readers access the blog daily, with an average of 2. That is, there are about 14, blog accesses every day. About half of the usage is international. Other strong and highly informed intellectual contributors have joined me in researching and authoring materials for the blog, Jim Watson in particular as a very strong partner.
Also I need mention Melody Winnig, a researcher-writer who performs important daily research literature surveillance for me and Jim. As time progressed, the process of updating this treatise has became increasingly daunting, in part because its organization no longer reflects how I now think about longevity or longevity-related interventions.
By about mid I was updating this treatise only selectively and somewhere in the middle of I gave up doing that completely except for listing blog entry links. Many of these are, however, covered fairly comprehensively in blog entries. Readers with particular interests are invited to check over the listings of blog entries included here.
As to shift over time of my overall perspective, a central observation is that I no longer view the theories of aging described here as independent or even necessarily fundamental.
They are all part of an emerging new grand unified theory GUT of biology. For example, REDOX processes, central to the first theory of aging, actually play significant roles in each of the other theories.
Some like lipofuscin accumulation, telomere shortening and tissue glycation and even cancers and heart diseases are definitely downstream in the causal chain. I expect to be forwarding the development of that GUT in close cooperation with Jim Watson, and at some point this will become the subject of a new book.
Another key observation is the importance of researching and drawing together discoveries from across a wide spectrum of disciplines — be the publications drawn from the literatures of genetics, epigenetics, cancer research, research in other specific diseases, cell components like mitochondria or microtubules, stem cells, plant biology, dose-responses, biogerentology, biochemistry of proteins, etc.
Relatively few of our citations are drawn from the works of researchers primarily involved in the field of aging.
Sadly but probably necessarily, most researchers work in disciplinary areas where there is great emphasis on depth of detail but where there is little time to encompass or integrate in discoveries from other disciplines.
I believe the blog has been able to surface a number of important original insights by bringing together and interpreting discoveries drawn from different disciplines in new contexts.For unlimited access to expert opinion and unrivalled insight from The Telegraph, join Premium today.
Free for 30 days. For unlimited access to expert opinion and unrivalled insight from The Telegraph, join Premium today. Free for 30 days. Priests for Life PO Box • Cocoa, FL Tel. , • [email protected] “It’s not clear that Trump’s end-of-the-campaign rhetoric about the caravan actually had any impact,” says John Sides, professor of political science at George Washington University.
Newsela is an Instructional Content Platform that supercharges reading engagement and learning in every subject. Despite the potential promise of new cell-based therapeutic approaches, unproven stem cell treatments for various ailments including lung diseases are a growing global problem ().Notably, an increasing number of outfits offer expensive, cell-based therapies that are biologically implausible, known to be ineffective, or have no proven benefit.